Lecture Outline

Lecture Day 1

• Introduction to structural bioinformatics
• Fundamentals of protein structure
• Demonstration using DeepView

Lecture Day 2

• Bioinformatics and evolutionary biology concepts
• Comparative homology modeling
• Demonstration using DeepView

Bioinformatics websites

Links to Structural Bioinformatics resources.

• DeepView - A macromolecular visualization tool

• RCSB Protein Data Bank - Database of protein structures

• ExPASy Proteomic Tools - A list of valuable proteomics tools

Links to Other Bioinformatics resources.

• NCBI homepage - A resource for bioinformatics tools and databases
• Align - Pairwise alignment tool at EBI
• BLAST - BLAST at NCBI
• ClustalW - Multiple sequence alignment tool and phylogenetic tree building tool at EBI
• Tcoffee - A rigorous multiple sequence alignment tool
• ExPASy homepage - A resource for bioinformatics tools and protein databases
• EBI homepage - A resource for bioinformatics tools and protein databases

Introduction to Structural Bioinformatics with DeepView

This module will introduce undergraduate students to structural bioinformatics using DeepView. Structural bioinformatics is a subfield of bioinformatics that centers on the structural aspects of protein and RNA sequences. DeepView is a free macromolecular visualization tool that enables the user to manipulate and analyze protein, DNA, and RNA 3D structures.